American Express’ latest travel report identifies **mid-sized cities** as unexpected hotspots for business travel—shifting focus away from traditional coastal hubs like New York, Los Angeles, and San Francisco. Analyzing year-over-year growth in hotel and airline bookings among commercial clients, the study highlights cities experiencing both population booms and surging business interest. Below are the standout destinations:
### Richmond, Virginia
A home to Fortune 500 giants (Performance Food Group, CarMax, Altria, Dominion Energy), Richmond is attracting companies via incentive-driven business expansion policies. Virginia has secured over $100 billion in capital investment commitments from corporate expansions statewide, Governor Glenn Youngkin announced in March. The city is also transforming through major developments: the **Richmond Diamond District** (converting 67 acres into a mixed-use neighborhood) and the **City Center Innovation District**, both designed to meet demand and lure businesses.
### Columbus, Ohio
With over 240 startups, Columbus has emerged as a hub for biotech and tech firms specializing in AI innovation. Census data confirms it as a Midwestern growth engine, with a population nearing 1 million—fueling business interest in the city.
### Charleston, South Carolina
Beyond its beaches and historic charm, Charleston is booming with tech, aerospace, and automotive companies setting up shop. Tourism revenue hit a record $14.03 billion in 2024 (a 7.1% jump from 2023), drawing corporate attention. Ingevity, a specialty chemical manufacturer, reinforced the city’s appeal with a $53 million, five-year investment in its Charleston County facility last year. “This commitment underscores confidence in our community and positions Charleston County as a leader in innovation and sustainable growth,” said County Council Chairman Herbert Ravenel Sass III.
### Boise, Idaho
Boise saw explosive post-pandemic growth: HireAHelper data shows four times more people moved to the city than left in 2020, driven by Western U.S. migrants. Its population grew from ~230,000 in 2020 to ~237,000 today. This surge has spurred business expansions in software, cleantech, and outdoor lifestyle sectors.
### New Orleans, Louisiana
Walkability, a compact layout, and unique culture are driving business to New Orleans, while city investments in venue infrastructure aim to attract conventions, create jobs, and boost the economy. Recently, 1834 Ventures launched a $20 million fund to back startups founded by Tulane University alumni, strengthening economic mobility. The fund seeks to “build a more vibrant startup ecosystem” and “diversify Louisiana’s economy,” per Louisiana Economic Development.